DOTAREM 0.5 MG 10 ML

DOTAREM 0.5 mmol/mL Solution for Injection

DOTAREM 0.5 mmol/mL Solution for Injection is a powerful and essential prescription diagnostic contrast agent manufactured by Guerbet.

This sterile, clear, colorless to pale yellow solution contains Gadoterate Meglumine, a gadolinium-based contrast agent (GBCA), specifically designed for intravenous administration to enhance visualization during Magnetic Resonance Imaging (MRI) scans.

As a widely trusted agent, DOTAREM significantly improves the contrast between normal and abnormal structures, aiding healthcare professionals in the precise diagnosis of a wide array of medical conditions affecting the brain, spine, and other body regions.

Its application allows for clearer, more detailed diagnostic images, which are critical for accurate medical assessment and treatment planning.

DOTAREM is known for its high relaxivity and excellent safety profile, making it a preferred choice in radiology departments globally.

Benefits of Use

• Enhances MRI image clarity, providing superior diagnostic information for various pathologies.
• Aids in the detection and delineation of lesions in the brain, spine, and associated tissues.
• Facilitates accurate assessment of blood-brain barrier disruption, tumor vascularity, and inflammatory processes.
• Supports differential diagnosis by improving lesion characterization.
• Offers a favorable safety profile with extensive clinical experience.

How to Use

1. DOTAREM must only be administered by qualified healthcare professionals trained in the use of MRI contrast agents.
2. The recommended dose is typically 0.1 mmol per kilogram of body weight, administered as a single intravenous bolus injection.
3. Ensure the injection site is clean and sterile, and administer the solution slowly over a few seconds.
4. Flush the intravenous line with a saline solution immediately after injection to ensure complete administration of the contrast agent.
5. MRI scanning should commence shortly after administration to capture the optimal contrast enhancement.
6. Refer to the prescribing information for specific dosing recommendations based on patient age, weight, and the type of MRI examination.

Caution & Warnings

• Strictly for intravenous use. Do not administer intrathecally.
• Patients with severe renal impairment are at risk of Nephrogenic Systemic Fibrosis (NSF); consult a physician regarding use.
• Hypersensitivity reactions, including anaphylactoid reactions, may occur. Facilities for resuscitation should be readily available.
• Administer with caution in patients with a history of allergic reactions, asthma, or other allergic disorders.
• Pregnancy and breastfeeding: Use only if clearly needed and the potential benefits outweigh the risks.
• Keep out of reach of children.
• Dispose of unused product and waste material in accordance with local requirements.

Ingredients

Each mL of DOTAREM contains 0.5 mmol of Gadoterate Meglumine. Other ingredients include meglumine, gadoteric acid, and water for injection.

Product Details

• Brand: GUERBET
• Manufacturer: Guerbet
• Form: Solution for Injection
• Strength: 0.5 mmol/mL
• Package Size: Typically supplied in 10 mL vials or pre-filled syringes.
• Administration Route: Intravenous
• Drug Type: Prescription Diagnostic Contrast Agent